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Regeneration is
in our genes.

Transforming treatment of severe disease with genetic medicines for tissue regeneration and organ repair.

About us

YAP Therapeutics, a Fjord Ventures Company, was founded with technology licensed from Texas Heart Institute and Baylor College of Medicine to develop and commercialize genetic medicines that regenerate tissue and repair organs for patients suffering from severe disease.

About Us

Technology

The YAPtx technology platform for regeneration and antifibrosis has its roots in modulation of Hippo/ YAP signaling as well as other related pathways. The genetic medicines under development are designed to unlock the regenerative capacity naturally contained within our DNA. These medicines will be delivered via recombinant viral vectors (like AAV) and next generation non-viral means. YAPtx is deploying its technology platform in order to realize the full potential of regenerative medicine to repair organs and cure severe disease for millions of patients.

Technology
News & Publication
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News & Publications

Nature | Hippo pathway deficiency reverses systolic heart failure after infarction
Leach JP, Heallen T, Zhang M, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550(7675):260-264. doi:10.1038/nature24045
 
Science Translational Medicine | Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction
Liu S, Li K, Wagner Florencio L, et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med. 2021;13(600):eabd6892. doi:10.1126/scitranslmed.abd6892
 
Nature Reviews Cardiology | Gene therapy against Hippo triggers cardiomyocyte renewal after MI
Fernández-Ruiz I. Gene therapy against Hippo triggers cardiomyocyte renewal after MI. Nat Rev Cardiol. 2021;18(9):611. doi:10.1038/s41569-021-00602-8
 
Circulation | Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction
Zhang S, Liu S, Leach JP, Li K, Perin EC, Martin JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022;146(20):1558-1560. doi:10.1161/CIRCULATIONAHA.122.059972
Contact
Contact

Thanks for contacting YAP Therapeutics.

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